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Hand-Schüller-Christian disease - Skull - Photomicrograph
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Hand-Schüller-Christian disease - Skull - Photomicrograph
  • Case ID: 446
  • Diagnosis: Hand-Schüller-Christian disease
  • Category: Histiocytoses
  • Category Type: Hand-Schüller-Christian disease
  • Category Sub Type: Benign
  • Location: Skull
  • Age: 6
  • Sex: F
  • Treatment: Chemotherapy
  • Image ID: 2852
  • Image Type: Photomicrograph
  • Images relating to this case: 2848 , 2849 , 2850 , 2851 , 2852.

Low power photomicrograph shows granulation tissue infiltrated by cholesterol clefts, a characteristic finding in Hand-Schüller-Christian disease. Erdheim-Chester disease has the same clinical picture but occurs in the fifth or sixth decade of life. It is a xantho-granulomatous histiocytosis seen in older patients and has a radiographic picture similar to that of Hand-Schüller-Christian disease.


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