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Juxta-articular chondroma Kaposi's Sarcoma Large cell lymphoma, Leimyosarcoma, Leiomyosarcoma, Letterer-Siwe disease, Leukemia, Low-grade intramedullary osteogenic sarcoma, Lumbosacral lipoma, Lymphangioma, Lymphangiomatosis, Lymphoma, Lymphoma pseudotumor (Actual: radiation osteitis), Lymphoma pseudotumor (Actual: stress fracture), Lymphoma with secondary osteogenic sarcoma Maffucci's Syndrome, Maligant fibrous histiocytoma pseudotumor (Actual: Hematoma), Malignant fibrous histiocytoma (MFH).
Letterer-Siwe disease - Skeleton - X-ray
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Letterer-Siwe disease - Skeleton - X-ray
  • Case ID: 447
  • Diagnosis: Letterer-Siwe disease
  • Category: Histiocytoses
  • Category Type: Letterer-Siwe disease
  • Category Sub Type: Benign
  • Location: Skeleton
  • Age: 3
  • Sex: F
  • Treatment: Chemotherapy
  • Image ID: 2853
  • Image Type: X-ray
  • Images relating to this case: 2853, 2854 , 2855 , 2856 , 2857 , 2858 , 2859 .

A 3-year-old female presented with a fever, weight loss, anemia and generalized aches and pains throughout the entire body. This lateral radiograph of the skull shows diffuse, geographic, lytic changes throughout the entire skull, similar to that of Hand-Schüller-Christian disease but more permeative in nature.


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