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Juxta-articular chondroma Kaposi's Sarcoma Large cell lymphoma, Leimyosarcoma, Leiomyosarcoma, Letterer-Siwe disease, Leukemia, Low-grade intramedullary osteogenic sarcoma, Lumbosacral lipoma, Lymphangioma, Lymphangiomatosis, Lymphoma, Lymphoma pseudotumor (Actual: radiation osteitis), Lymphoma pseudotumor (Actual: stress fracture), Lymphoma with secondary osteogenic sarcoma Maffucci's Syndrome, Maligant fibrous histiocytoma pseudotumor (Actual: Hematoma), Malignant fibrous histiocytoma (MFH).
Letterer-Siwe disease - Skeleton - X-ray
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Letterer-Siwe disease - Skeleton - X-ray
  • Case ID: 447
  • Diagnosis: Letterer-Siwe disease
  • Category: Histiocytoses
  • Category Type: Letterer-Siwe disease
  • Category Sub Type: Benign
  • Location: Skeleton
  • Age: 3
  • Sex: F
  • Treatment: Chemotherapy
  • Image ID: 2855
  • Image Type: X-ray
  • Images relating to this case: 2853 , 2854 , 2855, 2856 , 2857 , 2858 , 2859 .

This AP radiograph of the chest and shoulders shows extensive osteolytic destruction of every bone seen, including the ribs, proximal humeri, and scapulae and both clavicles that would suggest a malignant process such as a lymphoma, metastatic neuroblastoma or leukemia. In this case, the diagnosis was Letterer-Siwe disease.


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