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Juxta-articular chondroma Kaposi's Sarcoma Large cell lymphoma, Leimyosarcoma, Leiomyosarcoma, Letterer-Siwe disease, Leukemia, Low-grade intramedullary osteogenic sarcoma, Lumbosacral lipoma, Lymphangioma, Lymphangiomatosis, Lymphoma, Lymphoma pseudotumor (Actual: radiation osteitis), Lymphoma pseudotumor (Actual: stress fracture), Lymphoma with secondary osteogenic sarcoma Maffucci's Syndrome, Maligant fibrous histiocytoma pseudotumor (Actual: Hematoma), Malignant fibrous histiocytoma (MFH).
Letterer-Siwe disease - Skeleton - Photomicrograph
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Letterer-Siwe disease - Skeleton - Photomicrograph
  • Case ID: 447
  • Diagnosis: Letterer-Siwe disease
  • Category: Histiocytoses
  • Category Type: Letterer-Siwe disease
  • Category Sub Type: Benign
  • Location: Skeleton
  • Age: 3
  • Sex: F
  • Treatment: Chemotherapy
  • Image ID: 2858
  • Image Type: Photomicrograph
  • Images relating to this case: 2853 , 2854 , 2855 , 2856 , 2857 , 2858, 2859 .

A biopsy from one of the iliac lesions revealed a large number of aggressive histiocytes with inflammatory cells, including polymorphs, lymphocytes, a few esosinophils and an occasional giant cell scattered throughout. This is the charateristic histology of Letterer-Siwe disease. It is unusual to see foam cells in this syndrome.


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