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Juxta-articular chondroma Kaposi's Sarcoma Large cell lymphoma, Leimyosarcoma, Leiomyosarcoma, Letterer-Siwe disease, Leukemia, Low-grade intramedullary osteogenic sarcoma, Lumbosacral lipoma, Lymphangioma, Lymphangiomatosis, Lymphoma, Lymphoma pseudotumor (Actual: radiation osteitis), Lymphoma pseudotumor (Actual: stress fracture), Lymphoma with secondary osteogenic sarcoma Maffucci's Syndrome, Maligant fibrous histiocytoma pseudotumor (Actual: Hematoma), Malignant fibrous histiocytoma (MFH).
Letterer-Siwe disease - Skeleton - Photomicrograph
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Letterer-Siwe disease - Skeleton - Photomicrograph
  • Case ID: 447
  • Diagnosis: Letterer-Siwe disease
  • Category: Histiocytoses
  • Category Type: Letterer-Siwe disease
  • Category Sub Type: Benign
  • Location: Skeleton
  • Age: 3
  • Sex: F
  • Treatment: Chemotherapy
  • Image ID: 2859
  • Image Type: Photomicrograph
  • Images relating to this case: 2853 , 2854 , 2855 , 2856 , 2857 , 2858 , 2859.

Low power photomicrograph shows large numbers of pale-staining histiocytes. Scattered throughout are polymorphs and eosinophils, along with several giant cells that are seen typically in the histiocytoses. In this case, the patient's clinical picture was very acute and progessed rapidly. She died a leukemic-type death within a matter of six months despite attempts at chemotherapeutic suppression of the disease.


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