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Juxta-articular chondroma Kaposi's Sarcoma Large cell lymphoma, Leimyosarcoma, Leiomyosarcoma, Letterer-Siwe disease, Leukemia, Low-grade intramedullary osteogenic sarcoma, Lumbosacral lipoma, Lymphangioma, Lymphangiomatosis, Lymphoma, Lymphoma pseudotumor (Actual: radiation osteitis), Lymphoma pseudotumor (Actual: stress fracture), Lymphoma with secondary osteogenic sarcoma Maffucci's Syndrome, Maligant fibrous histiocytoma pseudotumor (Actual: Hematoma), Malignant fibrous histiocytoma (MFH).
Letterer-Siwe disease - Skeleton - X-ray
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Letterer-Siwe disease - Skeleton - X-ray
  • Case ID: 448
  • Diagnosis: Letterer-Siwe disease
  • Category: Histiocytoses
  • Category Type: Letterer-Siwe disease
  • Category Sub Type: Benign
  • Location: Skeleton
  • Age: 1
  • Sex: M
  • Treatment: Chemotherapy
  • Image ID: 2860
  • Image Type: X-ray
  • Images relating to this case: 2860, 2861 , 2862 , 2863 .

A 15-month-old boy presented with a fever, anemia, malaise, loss of weight and generalized osteolytic changes throughout the entire skeletal system. This lateral radiograph of the skull shows aggressive lytic destructive changes throughout the entire calvarium, some of which are geographic in nature with sharp margination, suggesting a histiocytic process such as Hand-Schüller-Christian disease or Letterer-Siwe disease, which is the case here.


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