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Juxta-articular chondroma Kaposi's Sarcoma Large cell lymphoma, Leimyosarcoma, Leiomyosarcoma, Letterer-Siwe disease, Leukemia, Low-grade intramedullary osteogenic sarcoma, Lumbosacral lipoma, Lymphangioma, Lymphangiomatosis, Lymphoma, Lymphoma pseudotumor (Actual: radiation osteitis), Lymphoma pseudotumor (Actual: stress fracture), Lymphoma with secondary osteogenic sarcoma Maffucci's Syndrome, Maligant fibrous histiocytoma pseudotumor (Actual: Hematoma), Malignant fibrous histiocytoma (MFH).
Letterer-Siwe disease - Skeleton - Photomicrograph
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Letterer-Siwe disease - Skeleton - Photomicrograph
  • Case ID: 448
  • Diagnosis: Letterer-Siwe disease
  • Category: Histiocytoses
  • Category Type: Letterer-Siwe disease
  • Category Sub Type: Benign
  • Location: Skeleton
  • Age: 1
  • Sex: M
  • Treatment: Chemotherapy
  • Image ID: 2863
  • Image Type: Photomicrograph
  • Images relating to this case: 2860 , 2861 , 2862 , 2863.

Low power photomicrograph shows large, pale-staining histiocytes infiltrated by a large number of inflammatory polymorphs, lymphocytes and eosinophils with an occasional giant cell, characteristic of Letterer-Siwe disease. This patient had extensive visceral involvement including the lungs, liver, spleen, lymph nodes and skin. He was begun on adjuvant chemotherapy but died a leukemic-type death within 11 months.


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