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Juxta-articular chondroma Kaposi's Sarcoma Large cell lymphoma, Leimyosarcoma, Leiomyosarcoma, Letterer-Siwe disease, Leukemia, Low-grade intramedullary osteogenic sarcoma, Lumbosacral lipoma, Lymphangioma, Lymphangiomatosis, Lymphoma, Lymphoma pseudotumor (Actual: radiation osteitis), Lymphoma pseudotumor (Actual: stress fracture), Lymphoma with secondary osteogenic sarcoma Maffucci's Syndrome, Maligant fibrous histiocytoma pseudotumor (Actual: Hematoma), Malignant fibrous histiocytoma (MFH).
Letterer-Siwe disease - Skeleton - X-ray
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Letterer-Siwe disease - Skeleton - X-ray
  • Case ID: 450
  • Diagnosis: Letterer-Siwe disease
  • Category: Histiocytoses
  • Category Type: Letterer-Siwe disease
  • Category Sub Type: Benign
  • Location: Skeleton
  • Age: 2
  • Sex: F
  • Treatment: Chemotherapy
  • Image ID: 2866
  • Image Type: X-ray

IMAGE DESCRIPTION:
This lateral radiograph of the skull of a 2-year-old girl shows extensive lytic destruction of the entire calvarium with a geographic margin suggesting a generalized histiocytosis, such as Hand-Schüller-Christian disease or Letterer-Siwe disease. This patient also had involvement of the viscera, skin, otitis media, enlarged liver and spleen, and lymphadenopathy with a generalized bone marrow depression. In spite of the use of chemotherapy, the patient died six months after the diagnosis of Letterer-Siwe disease.

 

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