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Juxta-articular chondroma Kaposi's Sarcoma Large cell lymphoma, Leimyosarcoma, Leiomyosarcoma, Letterer-Siwe disease, Leukemia, Low-grade intramedullary osteogenic sarcoma, Lumbosacral lipoma, Lymphangioma, Lymphangiomatosis, Lymphoma, Lymphoma pseudotumor (Actual: radiation osteitis), Lymphoma pseudotumor (Actual: stress fracture), Lymphoma with secondary osteogenic sarcoma Maffucci's Syndrome, Maligant fibrous histiocytoma pseudotumor (Actual: Hematoma), Malignant fibrous histiocytoma (MFH).
Giant cell tumor - Tibia - X-ray
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Giant cell tumor - Tibia - X-ray

On this AP radiograph taken five months later, there are destructive lytic changes throughout the entire proximal tibial metaphyseal-diaphyseal area extending up to the subchondral bone and clear across to the opposite tibial plateau and extensive cortical breakout on the medial and extensive soft tissue involvement outside the tibial cortex. There is no evidence of matrix calcification. At this point, the most likely diagnosis would be an aggressive giant cell tumor, however, the possibility of a hemorrhagic osteosarcoma must also be considered.


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